{"product_id":"mots-c","title":"MOTS-c","description":"\u003ch2\u003eDescription\u003c\/h2\u003e\n\u003cp\u003eMOTS-c is a 16-amino acid peptide encoded by an open reading frame in the \u003cstrong\u003emitochondrial 12S rRNA\u003c\/strong\u003e gene — one of the first mitochondrially-encoded peptides discovered. In research, MOTS-c is studied as a regulator of metabolic homeostasis, AMPK signaling, and communication between mitochondria and the cell nucleus.\u003c\/p\u003e\n\u003cp\u003eThe MOTS-c lyophilisation product is produced according to high quality standards and verified with HPLC to a purity of ≥ 99%.\u003c\/p\u003e\n\u003ch2\u003eSpecification Table\u003c\/h2\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003cth\u003eSpecification\u003c\/th\u003e\n\u003cth\u003eValue\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSample\u003c\/td\u003e\n\u003ctd\u003eMOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eCAS number\u003c\/td\u003e\n\u003ctd\u003e1627580-64-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e± 99+ % (HPLC – COA available)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular formula \/ weight\u003c\/td\u003e\n\u003ctd\u003eC₁₀₀H₁₅₂N₂₈O₂₂S₂ \/ 2173 Da\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSequence\u003c\/td\u003e\n\u003ctd\u003eMet-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAnalysis lab\u003c\/td\u003e\n\u003ctd\u003eJanoshik Independent Peptide Analytics\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eForm\u003c\/td\u003e\n\u003ctd\u003eLyophilisation product (dry powder)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eStorage conditions\u003c\/td\u003e\n\u003ctd\u003eStore refrigerated, protected from light and moisture\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch2\u003eResearch Relevance\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMitochondrial-nuclear communication\u003c\/strong\u003e — classic research tool for mito-nuclear signaling.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAMPK activation\u003c\/strong\u003e — models around metabolic stress response and glucose homeostasis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInsulin sensitivity\u003c\/strong\u003e — preclinical studies on metabolic flexibility and obesity resistance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAging and mitochondrial fitness\u003c\/strong\u003e — study of MOTS-c levels in relation to biological age.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIndependently tested by Janoshik Independent Peptide Analytics for purity, heavy metals and endotoxins.\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eWhat is MOTS-c?\u003c\/strong\u003e\u003cbr\u003eMOTS-c is a 16-amino acid mitochondrially-encoded peptide. It is biologically unusual because it is written in the mitochondrial genome itself, not in nuclear DNA — and it acts on nuclear gene expression.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is MOTS-c considered a ‘hormonal mitochondrial signal’?\u003c\/strong\u003e\u003cbr\u003eMOTS-c is actively secreted from mitochondria and affects distant tissues via AMPK signaling. This makes it one of the first confirmed mitochondrially-derived peptide hormones.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhat purity is guaranteed?\u003c\/strong\u003e\u003cbr\u003eJanoshik validates each batch for HPLC purity ≥ 99%, with additional analysis of heavy metals and endotoxins.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow is MOTS-c stored?\u003c\/strong\u003e\u003cbr\u003eStore the lyophilisation product refrigerated (2–8 °C), protected from light and moisture. Only open vials just before reconstitution for optimal peptide integrity.\u003c\/p\u003e\n\u003cblockquote\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e Intended for research purposes only. Not intended for human or animal consumption, medical, diagnostic, therapeutic or cosmetic applications. Buyer is 18+ and confirms the research context.\u003c\/p\u003e\n\u003c\/blockquote\u003e","brand":"PeptidesNova","offers":[{"title":"Default Title","offer_id":56882073960826,"sku":null,"price":24.95,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0936\/8017\/3434\/files\/ChatGPT_Image_13_mei_2026_21_25_49.png?v=1778700379","url":"https:\/\/peptidesnova.com\/products\/mots-c","provider":"Peptides Nova","version":"1.0","type":"link"}